GRIB. Research Unit on Biomedical Informatics





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Ready, set, go for crossing the barrier!

Genes contain all the information needed for the functioning of cells, tissues, and organs in our body. Gene expression, meaning when and how are the genes being read and executed, is thoroughly regulated like an assembly line with several things happening one after another.

Researchers at the Centre for Genomic Regulation (CRG) in collaboration with the Structural Bioinformatics group of GRIB (IMIM-UPF) led by Baldo Oliva and the Department of Molecular Epigenetics, Helmholtz Center Munich, Germany, have discovered a new step in this line, which controls the expression of some genes with an important role in cancer. "We observed that breast cancer cells need a particular modification to express a set of genes required for cellular proliferation and tumour progression," explains the CRG – Beatriu de Pinós postdoctoral researcher Priyanka Sharma, first author of the paper. "This modification allows the enzyme RNA polymerase II to overcome a pausing barrier and to continue to transcribe these genes," adds Sharma.

Reference article: Priyanka Sharma et al. "Arginine citrullination at the c-terminal domain controls RNA polymerase II transcription" Molecular Cell (2018) DOI: 10.1016/j.molcel.2018.10.01.

For press releases in spanish and catalan click here.

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Judith Pérez, winner of the collaborative poster session at the 2nd DCEXS PhD students' symposium

Congratulations to Judith Pérez, predoctoral researcher of the Integrative Biomedical Informatics Group of GRIB, awarded for the poster entitled "ResMarkerDB: a database of biomarkers of response to antibody therapy for breast and colorectal cancer". ResMarkerDB aims to promote the identification of existing and new actionable biomarkers of drug response in cancer and acts as a centralized repository that gathers information of biomarkers of response to therapeutic monoclonal antibodies for breast and colorectal cancer. Indeed, it integrates information from available public repositories and new data extracted and curated from the literature. Furthermore, ResMarkerDB allows exploration, visualization and prioritization of biomarker data and its response to therapy in a specific cancer type according to the evidence supporting their association and potential clinical usefulness. More information of this resource at http://resmarkerdb.org.

The poster session was part of the 2nd PhD students' symposium of the Department of Experimental and Health Sciences (DCEXS) held last 22&23rd of November in the PRBB. The DCEXS holds every year this symposium featuring leading topics in biomedical research, such as quantitative biology, genetics or neuroscience. Last year it was focused on doctoral students and this year it has been organized by a committee with representatives from all collectives.

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FAIRPlus

The project FAIRPlus aims to develop the guidelines and tools needed to make data FAIR: sharing data so that other researchers can Find, Access and Interoperate i.e. integrate the data with the outcomes of their own experiments - allows Reuse and an opportunity to build the large aggregated cohorts needed to detect rare signals and manage the many confounding factors in translational research. The project is funded by the Innovative Medicines Initiative (IMI2) together with the pharmaceutical industry for the period 2019-2021.

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